Palacio Astoreca, Valparaíso, Chile
Step into this sumptuous Cerro Alegre Victorian mansion with its grand red and white façade, and not only will you find seriously slick design sitting in harmony alongside historical artefacts, a sleek basement spa and utterly breathtaking views over Valparaíso Bay, but also the Alegre Restaurant, hailed by many as South America's best, run by acclaimed Spanish chef Sergio Barroso of El Bulli fame.